MPI Research continues to expand its ADME/PK testing requirements. The ADME group at MPI Research conducts a wide range of studies in support of both Discovery and Development programs for its Sponsors.

Our capabilities include radiotracer studies, which are routinely conducted using 14C, 3H, 35S, and 125I. Radiotracer studies with other isotopes can be conducted upon request. Formulation of test substances prior to animal administration is also performed on site. MPI Research has experience in conducting studies in rats, mice, rabbits, dogs, micro-pigs, and monkeys utilizing a variety of dosing routes. We perform mass balance, excretion, quantitative tissue distribution, and metabolic profiling by HPLC with radioactivity/UV detection.

We are qualified to conduct pharmacokinetic and toxicokinetic studies on site with a focus on blood/plasma concentrations, bioavailability, absorption and clearance along with pharmacokinetic analysis, and report preparation. Enterohepatic recirculation evaluation studies are conducted in the rat using a re-infusion model.

Dr. James Laveglia, Executive Vice President and Director of Research, commented, “The emerging role of ADME in optimizing Drug Discovery and Design is critical to drug development. MPI Research continues to focus on broadening our ADME capabilities to provide our sponsors with accurate information about their compounds. Additionally, MPI provides the resources to identify which animal species metabolizes your drug most closely to humans. Our Director of ADME, Dr. Mary Sherman, provides years of experience to this valuable discipline. Finally, a new state-of-the-art metabolism lab has just been completed, providing MPI with superior research facilities for conducting ADME research for our sponsors.”

MPI Research exists to provide comprehensive non-clinical research that meets the requirements of pharmaceutical, animal health and chemical companies as well as governmental agencies as we partner together to bring safer, healthier products to the world. MPI Research employees specialize in a wide variety of scientific disciplines including toxicology, pharmacology, metabolism, pathology, clinical pathology, reproductive and developmental biology, veterinary science, neuroscience, analytical chemistry, computer science, regulatory science, and statistics.

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