Targeted Discovery Research at MPI Research assists Sponsors with preclinical efficacy and safety testing. This unit's diversely trained team of scientific Research Associates and Study Directors has developed a range of models that expedite the discovery and development processes within the pharmaceutical and biotechnology industries. Additionally, the staff has experience in conducting studies involving human and rat stem cells.
Specialized routes of test article administration are available, including intravenous injection in rats and mice and central administration via stereotaxic placement of cannulas/catheters (intracerebral/intrathecal) and delivery of cell-based therapeutics in rodents. MPI Research Sponsors also benefit from the in vitro support services which include a tissue culture facility and in
vitro facility, a BSL-2 laboratory for handling pathogens, and GLP-compliant cell biology and flow cytometry laboratory.
Services/Capabilities
Cell- and Gene-Based Therapeutic Models
- Surgical expertise in delivering cell-based test articles to various anatomic locations (rodents and nonhuman primates)
- Extensive experience with immunocompromised rodents and the use of immunosuppressants
Screening
Models for Pain
- Mouse writhing
- Rodent tail flick, hot plate,
modified Hargreave’s
- Nonhuman primates warm-water
tail withdrawal (analgesia, hyper-analgesia)
Tumor Models for Anticancer Drug Discovery
- Human tumor xenograft
models in immunocompromised rodents
- Rodent tumor models
Other
Disease Models
- Streptozotocin-induced diabetes
(rodents)
- Hypoglycemia and glucose tolerance
tests (rodents and nonhuman primate)
- Weight gain/prevention studies
(rodents)
- Atherosclerosis (rodents)
Infectious
Disease Models
- Rodent bacteremia/peritonitis
- Chinchilla acute otitis media
(Haemophilus influenzae)
- Vaccine efficacy and safety studies
(rodents and dogs)
Immunoassays
- Flow cytometry (intracellular
cytokine, cell surface markers,
apoptosis, etc.)
- Cell proliferation (BrdU and
metabolic indices)
- Phenotypic characterization of
different cell types by flow cytometry
- Immunoassay (ELISA and electrochemiluminescence
instruments: BioVeris and Meso-Scale
Discovery)
- Customized assay development
Immunohistochemistry
- Numerous special stains procedures in addition to immunofluorescence and immunohistochemical techniques
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For more detailed information
about the experimental therapeutic services
offered by MPI Research, please contact TDR@mpiresearch.com or
call 269.668.3336, Ext. 1120.
Home | Services/Capabilities
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